Drugs Affecting the Cardiovascular System

Drugs Affecting the Cardiovascular System
Order 59989001
Drugs Affecting the Cardiovascular System
1. Which of the following is true concerning nitrates?
A. They constrict meningeal blood vessels causing head¬
aches
B. They are more effective as a prophylactic measure
taken daily than taken to relieve an anginal attack
C. They usually decrease venous return
D. They are selective coronary dilators with little if
any effects elsewhere
E. Nitroglycerine is administered under the tongue
since if swallowed it would be destroyed by the gas¬
tric juice
79
Drugs Affecting the Cardiovascular System
80 / Pharmacology
214. Quinidine
A. increases myocardial contraction force
B. prolongs the refractory period (ERP) and the action
current without changing the rate of depolarization
or changing the membrane resting potential
C. lengthens the ERP, depresses myocardial depolariza¬
tion and rate of phase 0 depolarization, does not
change the resting membrane potential, and does
not prolong the action current duration
D. reduces the rate of Na outflow during depolariza¬
tion
E. may be used in patients with myasthenia gravis
since it does not share with quinine the weakening
effect on skeletal muscles
2. Which of the following is true concerning antiarrhythmic drugs?
A. Quinidine, procainamide, phenytoin, and lidocaine
are drugs of class 3 type
B. Bretylium and solatol are class 4 type characterized
by blocking the slow inward flow of calcium (cal¬
cium blocker)
C. Class I type is most effective against atrial and A-V
junctional arrhythmias
D. Recently verapamil, a /3-adrenergic blocker, has be¬
come available for treatment of supraventricular
arrhythmia
E. None of the above
216. By what mechanism do veratrum alkaloids lower the
blood pressure?
A. Decreased heart rate by direct action on S-A node
B. Direct action on the emetic center causing nausea
and vomiting
C. Direct action on blood vessels causing vasodilation
D. Direct action on carotid sinus and baroreceptors in
aorta and elsewhere which cause inhibition of CNS
vasoconstriction center and increased vagal action of
CNS origin
E. None of the above
The Cardiovascular System / 81
217. In the therapy of congestive heart failure, the most
important pharmacologic action of digitalis is its ability
to
Drugs Affecting the Cardiovascular System
A. produce diuresis in edematous patients
B. reduce venous pressure
C. increase myocardial contractile force
D. increase heart rate
E. decrease pacemaker automaticity in cells of the
bundle of His
218. Of the following cardiac glycosides, which has the clear¬
ly superior (larger) therapeutic index?
A. Ouabain
B. Digoxin
C. Digitoxin
D. Deslanoside
E. None of the above is superior to the others
219. In the course of treating a congestive heart failure pa¬
tient with a cardiac glycoside, you observe that the
patient’s resting heart rate, which previously had been
80/min is now 40/min. This would
A. probably be unrelated to drug administration
B. be the desired response to the drug
C. probably be the result of a drug-induced heart
block
D. be an indication for increasing the drug dose
E. suggest the addition of quinidine to the therapeutic
regimen
220. Digoxin differs from digitoxin in that digoxin
A. has a longer half-life
B. is completely absorbed from the GI tract
C. has a half-life that is more dependent on the ad
equacy of renal function
D. is bound extensively to plasma proteins
E. is metabolized extensively by the liver
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