Chemical biology concepts

1 Chemical biology concepts
a) Brie y explain the dierence between the Pzer/Moderna and Johnson & Johnson vaccines.
How is each one delivered? Does it go into the nucleus or stay in the cytoplasm? What is
the actual antigen that generates the immune response? (8 points)
1
2 Mechanisms and molecular structure
a) The modied nucleotide is used in the Pzer coronavirus vaccine. Draw the structure of
. Explain which base is replaced with and why this modication is necessary. (8 points)
b) Draw a schematic illustrating how to use in vitro selection to make an RNA aptamer that
binds pyrrollsine, one of the natural amino acids used by archaea, but not eukaryotes or bac-
teria. (8 points)
c) Does lysine or arginine make stronger salt bridges with aspartic acid? Draw a picture to
explain your answer. (6 points)
2
3 Literature questions
These questions are about the Haurwitz et al 2010 paper about the Csy4 CRISPR endonuclease,
which is available on the class website.
a) In your own words, brie y explain what a CRISPR-Cas system is, and why is it important
in bacteria and archaea. (6 points)
b) In your own words, what is the biological function of Csy4? Why is there more than one
endonuclease in the CRISPR-Cas9 system? (What does Cas9 do and how is it dierent?) (6
points)
c) In your own words, please explain the experiment shown in Figure 3. What did the researchers
do? Describe the results and the quality control metric(s) used. It may be useful to refer to
the structures shown in Figure 2 in your explanation. (8 points)
3

Order any type of Service We Provide

We are the best assignment service that can satisfy student’s demands in different scientific fields. We perform tasks of any kind. Our specialists provide diverse custom assignment writing services to students from all over the world every day. You can contact us for assistance with:

• Essays of any type (application, scholarship, argumentative, personal, informative, persuasive, compare and contrast, narrative, analytical, cause and effect, critical, process, descriptive, expository essays);
• Homework,
• Assignments,
• Reviews of all types (for a book, an article, or a film),
• Reports,
• Annotated bibliography,
• Projects,
• Thesis,
• Term papers,
• Presentations,
• Lab works,
• Research papers,
• Speeches,
• Critical thinking,
• Capstone projects;
• Business plan;
• Coursework’s;
• Dissertations.

The list is far from complete!

Representatives of our student assignment service are connoisseurs of the peculiarities of presentation in regards to academics. Your college assignment will never turn out an untoward surprise! Whether you need research for high school, an undergraduate program, or a Master’s or Doctoral degree, you will get exactly what you are looking for to sound smart and well-informed.

If you are pressed for time, request our experts!

We are your academic saver. It is a perfect solution for people who need academic help but has no professionals nearby to provide it. Just redirect your home tasks to us and forget about any educational issues. With us, you will get 100% plagiarism-free content delivered on time by an experienced specialist in a particular field.

Main Advantages of Collaboration with Us

When you order professional assignments here, you will get:

Original custom papers. We value your academic reputation. Just as well, we value the years of thorough work on our reputation for reliability and never compromise the originality of delivered papers. We will never endanger both. Every custom assignment is written from zero – the only possible first stage of work on the order is research. We apply the latest plagiary checking tools on the final stage, so plagiarism has no chance to emerge in your college assignment writing.

Control over the order completion. To make the process of collaboration comfortable and efficient, we offer our clients to choose the writer themselves taking into account all the requirements and the budget. For you to save nerves, having entrusted your fateful task to some qualified “stranger”, we enable communication with the assigned writer in the process of order completion.

Affordable assistance. We are eager to contribute to the academic achievements of students in need of help with college assignments. We are eager to help you start investing in your career growth today. That is why our service is so affordable. We don’t charge to pay for the latest marketing tricks or advertisements – we choose the best experts in the labor market who write great custom papers in any area, level of complexity, and time frame. Our client’s grateful feedback is a top advertising trick.

On-time delivery. The quality of a paper is only valued when it is delivered within the determined time frame – you will get your custom assignment writing service in time and have a couple of days to revise it and ask for changes in case they are needed. And you will still have time to learn the material.

Protection. We value your trust and take all measures needed to keep your private and banking details safe. We offer only well-tested payment methods. Due to the system of encryption and protected servers, no third party can have access to your data.

Custom support 24/7. We do our best to make the process of collaboration comfortable for the customer. Our “write my assignment” help is always here for you to provide a solution to your problems, give you a prompt answer to any question, and offer clarification as to any issue related to the services. Feel free to contact us anytime!

If you feel that your dissatisfaction with student life is growing every day and you just feel exhausted, don’t hesitate to change the situation for the better today. Order your first assignment from reliable custom assignment services today to evaluate the advantages.

Having seen the difference once, you won’t want to go back to your previous lifestyle. You deserve to find fulfilment in other spheres of your life, have hobbies, spend time with close people but continue making progress. It is possible when you have a professional helper. Don’t put off your life for someday after graduation!

Order your paper now!