Buy Neuropathology Discussion Questions
Buy Neuropathology Discussion Questions
1. A 43-year-old South Asian man is brought
into the emergency department with generalized seizures and fever >38 (101F). CT head
does not show any abnormality. LP is performed with an opening pressure of 22 cm
H2O and CSF analysis shows: WCC 748
(Polymorphs 113, Lymphocytes 635), RBC
28, normal protein and normal glucose.
Which one of the following is the most likely
cause?
a. Enterovirus
b. Listeria monocytogenes
c. Mycobacterium tuberculosis
d. Streptococcus pneumoniae
e. Wegener’s granulomatosis
2. A 45-year-old woman presents with sudden
onset headache and photophobia. CT head
is unremarkable and she undergoes a lumbar
puncture. CSF analysis shows WCC 3, RBC
15000 and subarachnoid hemorrhage cannot
be excluded due to the presence of oxyhemoglobin. CSF xanthochromia is detected by
which one of the following assays?
a. Fluorescence in situ hybridization
b. Immunoprecipitation
c. Light microscopy
d. Spectroscopy
e. Western blotting
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3. Which one of the following is the most
appropriate marker for tumor proliferation?
a. GFAP
b. Ki-67
c. LDH
d. P53
e. S100
4. Which one of the following pathologies is
most likely to exhibit the finding shown?
a. Ataxia telangiectasia
b. Neurofibromatosis-1
c. Neurofibromatosis-2
d. Sturge-Weber syndrome
e. Tuberous sclerosis
5. Which one of the following is most accurate
regarding tumors with 0-6-methylguanineDNA methyltransferase methylation?
a. More susceptible to alkylating agents
b. More susceptible to antimetabolites
c. More susceptible to antitumor antibiotics
d. More susceptible to topoisomerase
inhibitors
e. More susceptible to ribunucleotide reductase inhibitors
6. Which one of the following genetic mutations are associated with improved brain
tumor prognosis?
a. Loss of 1p/19q
b. Loss of 1p/22q
c. Loss of 1p/10q
d. Loss of 1p/10q
e. Loss of 1p/10q
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