Order Principles of Pharmacology Assignment

Order Principles of Pharmacology Assignment
Order 5887490
Order Principles of Pharmacology Assignment
1. Different lots of a drug preparation have the same bio¬
availability when they
A. are chemically equivalent
B. fulfill the same chemical standards as set by regula¬
tory agencies
C. yield similar concentrations of the drug in blood and
tissues
D. have been approved by the Food and Drug Admin¬
istration (FDA)
E. meet the standards set forth by the United States
Pharmacopoeia (USP)
2. The addition of 1:50,000 epinephrine to a drug solu¬
tion to be administered subcutaneously slows its rate
of absorption by
A. decreasing permeability of the cells
B. vasoconstriction
C. competitive action for absorption
D. modification of the pH of the solution
E. interaction with the drug to render it less soluble
15
Order Principles of Pharmacology Assignment
3. Which of the following is true?
A. Partial pressure is that percentage of gas concentra¬
tion of an individual gas in a mixture of gases
B. The volume of a gas in a liquid is determined by its
partial pressure and its affinity for the liquid mole¬
cules and is known as Henry’s law
C. Partition coefficient (known as K) is the ratio of
concentration in the aqueous phase to concentration
in organic solvent
D. A drug with a high K passes slowly into cells by
diffusion
E. None of the above
4. Which of the following is true?
A. The rate of absorption and the rate of elimination
of drugs are usually equal
B. Plotted on an arithmetic scale drug elimination fol¬
lows a straight line
C. A constant fraction of the drug in the body is elim¬
inated per unit of time
D. The elimination half-time of a drug is one-half of
the time required for the elimination of all of the
drug
E. None of the above
45. A drug dose repeated at the elimination half-life will,
with that dose, approach the plateau level of further ad¬
ministrations by what percentage?
A. 50%
B. 62.5%
C. 75%
D. 82.5%
E. 90%
Principles of Pharmacology / 17
Order Principles of Pharmacology Assignment
46. The concept of receptor substance in cells was first pro¬
posed by
A. Paul Ehrlich
B. J. N. Langley
C. Sir Henry Dale
D. Torald Sollmann
E. A. R. Cushny
47. Passage of drugs through cell membranes is influenced
by all of these factors EXCEPT
A. its pH
B. its type of action
C. the amount of protein binding
D. its lipid solubility
E. presence of pores in the membrane
48. Barriers to penetration of drugs into tissues vary in their
effectiveness; which of the following is the most effec¬
tive?
A. Placenta early in pregnancy
B. Placenta late in pregnancy
C. Brain
D. Tunica propria of testes
E. Sertoli cells of testes
49. Adverse and undesirable drug effects are more likely to
occur with
A. oral ingestion
B. subcutaneous administration
C. intramuscular administration
D. intravenous administration
E. rectal administration
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