Order Adrenergic Drugs Discussion Questions

Order Adrenergic Drugs Discussion Questions
Order 5989213
Order Adrenergic Drugs Discussion Questions
Directions for questions 1−5
Match each adrenergic drug w ith the appropriate description
(each lettered option can be selected once, m ore than once, or not
at all).
A. Albuterol
B. Apraclonidine
C. Cocaine
D. Dextroam phetam ine
E. Dobutam ine
F. Dopam ine
G. Epinephrine
H. Isoproterenol
I. Methyldopa
J. Norepinephrine
K. Phenylephrine
L. Salm eterol
Di culty level: Easy
Order Adrenergic Drugs Discussion Questions
1. An α2 selective adrenoceptor agonist
Di culty level: Easy
2. A long-acting β2 selective adrenoceptor agonist
Di culty level: Easy
3. An indirect-acting adrenergic agent som etim es used as an
antihypertensive
Di culty level: Easy
4. A nonselective β1 adrenoceptor agonist
Di culty level: Easy
5. A selective α1 adrenoceptor agonist
Di culty level: Medium
6. A 75-year-old-wom an, hospitalized for breast cancer, was
found unconscious in her bed by a nurse. A diagnosis of cardiac arrest was m ade, and cardiopulm onary resuscitation
was started w ithout success. The electrocardiogram showed
that the patient was in asystole. An intracardiac injection of
epinephrine was given. Which of the follow ing postreceptor
m echanism s m ost likely m ediated the e ect of epinephrine
on cardiac contractility in this patient?
A. Opening of ligand-gated K channels
B. Opening of ligand-gated Na channels
C. Activation of phospholipase C
D. Activation of phospholipase A2
E. Activation of adenylyl cyclase
Di culty level: Medium
7. A 35-year-old m an was adm itted to the hospital follow ing a
car accident, and a blood transfusion was started. A few m inutes later, he com plained of nausea and pruritus and developed dyspnea w ith audible w heezing. His skin was m ottled
and cold, heart rate was 120 bpm , and blood pressure fell to
80/40 m m Hg. An intram uscular injection of epinephrine was
given. Which of the follow ing actions of the drug m ost likely
contributed to its therapeutic e cacy in this patient?
A. Increased glycogenolysis
B. β2 receptor−m ediated vasodilation
C. Stim ulation of platelet aggregation
D. Inhibition of insulin secretion
E. Inhibition of m ast cell degranulation
F. Stim ulation of eicosanoid biosynthesis
Di culty level: Medium
Order Adrenergic Drugs Discussion Questions
8. A 34-year-old wom an was at the dentist for an endodontic
procedure. Before starting the procedure, the dentist injected
a solution of lidocaine plus epinephrine near the tooth in
order to provide local anesthesia. The epinephrine-induced
increased duration of the lidocaine e ect was m ost likely m ediated by the activation of w hich of the follow ing adrenoceptors?
A. β1
B. β2
C. β3
D. α1
E. α2
Di culty level: Hard
9. A 51-year-old m an was adm itted to the coronary care unit
w ith a diagnosis of m yocardial infarction. Two hours later,
he developed ventricular brillation and was de brillated im –
m ediately, but w ithout success. Cardiopulm onary resuscitation (CPR) was started, and two additional shocks were given
at a higher energy, but the patient rem ained unresponsive. At
this tim e a bolus of intravenous epinephrine was given, w hile
continuing the CPR. Which of the follow ing receptor actions
of the drug best describes the rationale for adding epinephrine in this setting?
A. α1 receptor−m ediated vasoconstriction
B. β2 receptor−m ediated vasodilation
C. β2 receptor−m ediated increase in cardiac contractility
D. β1 receptor−m ediated increase in renin secretion
E. β2 receptor−m ediated bronchodilation
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